GlutaredoxinV1, Main, Exploration, bibRecord, 000329

Physical interaction between the MAPK Slt2 of the PKC1-MAPK pathway and Grx3/Grx4 glutaredoxins is required for the oxidative stress response in budding yeast.

Identifieur interne : 000329 ( Main/Exploration ); précédent : 000328; suivant : 000330

Physical interaction between the MAPK Slt2 of the PKC1-MAPK pathway and Grx3/Grx4 glutaredoxins is required for the oxidative stress response in budding yeast.

Auteurs : Nuria Pujol-Carrion [Espagne] ; Maria Angeles De La Torre-Ruiz [Espagne]

Source :

Free radical biology & medicine [ 1873-4596 ] ; 2017.

RBID : pubmed:28007574

Descripteurs français

English descriptors

Abstract

This study demonstrates that both monothiol glutaredoxins Grx3 and Grx4 physically interact with the MAPK Slt2 forming a complex involved in the cellular response to oxidative stress. The simultaneous absence of Grx3 and Grx4 provokes a serious impairment in cell viability, Slt2 activation and Rlm1 transcription in response to oxidative stress. Both in vivo and in vitro results clearly show that Slt2 can independently bind either Grx3 or Grx4 proteins. Our results suggest that Slt2 form iron/sulphur bridged clusters with Grx3 and Grx4. For the assembly of this complex, cysteines of the active site of each Grx3/4 glutaredoxins, glutathione and specific cysteine residues from Slt2 provide the ligands. One of the ligands of Slt2 is required for its dimerisation upon oxidative treatment and iron repletion. These interactions are relevant for the oxidative response, given that mutants in the cysteine ligands identified in the complex show a severe impairment of both cell viability and Slt2 phosphorylation upon oxidative stress. Grx4 is the relevant glutaredoxin that regulates Slt2 phosphorylation under oxidative conditions precluding cell survival. Our studies contribute to extend the functions of both monothiol glutaredoxins to the regulation of a MAPK in the context of the oxidative stress response.

DOI: 10.1016/j.freeradbiomed.2016.12.023
PubMed: 28007574

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000380
to stream Main, to step Curation: 000380

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Physical interaction between the MAPK Slt2 of the PKC1-MAPK pathway and Grx3/Grx4 glutaredoxins is required for the oxidative stress response in budding yeast.</title>
<author><name sortKey="Pujol Carrion, Nuria" sort="Pujol Carrion, Nuria" uniqKey="Pujol Carrion N" first="Nuria" last="Pujol-Carrion">Nuria Pujol-Carrion</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Basic Medical Sciences, IRB-Lleida. University of Lleida, Av. Alcalde Rovira Roure no 80, 25198 Lleida, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Basic Medical Sciences, IRB-Lleida. University of Lleida, Av. Alcalde Rovira Roure no 80, 25198 Lleida</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Torre Ruiz, Maria Angeles De La" sort="Torre Ruiz, Maria Angeles De La" uniqKey="Torre Ruiz M" first="Maria Angeles De La" last="Torre-Ruiz">Maria Angeles De La Torre-Ruiz</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Basic Medical Sciences, IRB-Lleida. University of Lleida, Av. Alcalde Rovira Roure no 80, 25198 Lleida, Spain. Electronic address: madelatorre@cmb.udl.cat.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Basic Medical Sciences, IRB-Lleida. University of Lleida, Av. Alcalde Rovira Roure no 80, 25198 Lleida</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Catalogne</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:28007574</idno>
<idno type="pmid">28007574</idno>
<idno type="doi">10.1016/j.freeradbiomed.2016.12.023</idno>
<idno type="wicri:Area/Main/Corpus">000380</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000380</idno>
<idno type="wicri:Area/Main/Curation">000380</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000380</idno>
<idno type="wicri:Area/Main/Exploration">000380</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Physical interaction between the MAPK Slt2 of the PKC1-MAPK pathway and Grx3/Grx4 glutaredoxins is required for the oxidative stress response in budding yeast.</title>
<author><name sortKey="Pujol Carrion, Nuria" sort="Pujol Carrion, Nuria" uniqKey="Pujol Carrion N" first="Nuria" last="Pujol-Carrion">Nuria Pujol-Carrion</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Basic Medical Sciences, IRB-Lleida. University of Lleida, Av. Alcalde Rovira Roure no 80, 25198 Lleida, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Basic Medical Sciences, IRB-Lleida. University of Lleida, Av. Alcalde Rovira Roure no 80, 25198 Lleida</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Torre Ruiz, Maria Angeles De La" sort="Torre Ruiz, Maria Angeles De La" uniqKey="Torre Ruiz M" first="Maria Angeles De La" last="Torre-Ruiz">Maria Angeles De La Torre-Ruiz</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Basic Medical Sciences, IRB-Lleida. University of Lleida, Av. Alcalde Rovira Roure no 80, 25198 Lleida, Spain. Electronic address: madelatorre@cmb.udl.cat.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Basic Medical Sciences, IRB-Lleida. University of Lleida, Av. Alcalde Rovira Roure no 80, 25198 Lleida</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Catalogne</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Free radical biology & medicine</title>
<idno type="eISSN">1873-4596</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term>
<term>Glutaredoxins (chemistry)</term>
<term>Glutaredoxins (metabolism)</term>
<term>MAP Kinase Signaling System (MeSH)</term>
<term>Mitogen-Activated Protein Kinases (chemistry)</term>
<term>Mitogen-Activated Protein Kinases (metabolism)</term>
<term>Oxidation-Reduction (MeSH)</term>
<term>Oxidative Stress (MeSH)</term>
<term>Oxidoreductases (chemistry)</term>
<term>Oxidoreductases (metabolism)</term>
<term>Phosphorylation (MeSH)</term>
<term>Protein Interaction Domains and Motifs (MeSH)</term>
<term>Protein Multimerization (MeSH)</term>
<term>Protein Processing, Post-Translational (MeSH)</term>
<term>Saccharomyces cerevisiae (enzymology)</term>
<term>Saccharomyces cerevisiae Proteins (chemistry)</term>
<term>Saccharomyces cerevisiae Proteins (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Glutarédoxines (composition chimique)</term>
<term>Glutarédoxines (métabolisme)</term>
<term>Maturation post-traductionnelle des protéines (MeSH)</term>
<term>Mitogen-Activated Protein Kinases (composition chimique)</term>
<term>Mitogen-Activated Protein Kinases (métabolisme)</term>
<term>Motifs et domaines d'intéraction protéique (MeSH)</term>
<term>Multimérisation de protéines (MeSH)</term>
<term>Oxidoreductases (composition chimique)</term>
<term>Oxidoreductases (métabolisme)</term>
<term>Oxydoréduction (MeSH)</term>
<term>Phosphorylation (MeSH)</term>
<term>Protéines de Saccharomyces cerevisiae (composition chimique)</term>
<term>Protéines de Saccharomyces cerevisiae (métabolisme)</term>
<term>Saccharomyces cerevisiae (enzymologie)</term>
<term>Stress oxydatif (MeSH)</term>
<term>Système de signalisation des MAP kinases (MeSH)</term>
<term>Séquence d'acides aminés (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Glutaredoxins</term>
<term>Mitogen-Activated Protein Kinases</term>
<term>Oxidoreductases</term>
<term>Saccharomyces cerevisiae Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glutaredoxins</term>
<term>Mitogen-Activated Protein Kinases</term>
<term>Oxidoreductases</term>
<term>Saccharomyces cerevisiae Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Glutarédoxines</term>
<term>Mitogen-Activated Protein Kinases</term>
<term>Oxidoreductases</term>
<term>Protéines de Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Glutarédoxines</term>
<term>Mitogen-Activated Protein Kinases</term>
<term>Oxidoreductases</term>
<term>Protéines de Saccharomyces cerevisiae</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>MAP Kinase Signaling System</term>
<term>Oxidation-Reduction</term>
<term>Oxidative Stress</term>
<term>Phosphorylation</term>
<term>Protein Interaction Domains and Motifs</term>
<term>Protein Multimerization</term>
<term>Protein Processing, Post-Translational</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Maturation post-traductionnelle des protéines</term>
<term>Motifs et domaines d'intéraction protéique</term>
<term>Multimérisation de protéines</term>
<term>Oxydoréduction</term>
<term>Phosphorylation</term>
<term>Stress oxydatif</term>
<term>Système de signalisation des MAP kinases</term>
<term>Séquence d'acides aminés</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">This study demonstrates that both monothiol glutaredoxins Grx3 and Grx4 physically interact with the MAPK Slt2 forming a complex involved in the cellular response to oxidative stress. The simultaneous absence of Grx3 and Grx4 provokes a serious impairment in cell viability, Slt2 activation and Rlm1 transcription in response to oxidative stress. Both in vivo and in vitro results clearly show that Slt2 can independently bind either Grx3 or Grx4 proteins. Our results suggest that Slt2 form iron/sulphur bridged clusters with Grx3 and Grx4. For the assembly of this complex, cysteines of the active site of each Grx3/4 glutaredoxins, glutathione and specific cysteine residues from Slt2 provide the ligands. One of the ligands of Slt2 is required for its dimerisation upon oxidative treatment and iron repletion. These interactions are relevant for the oxidative response, given that mutants in the cysteine ligands identified in the complex show a severe impairment of both cell viability and Slt2 phosphorylation upon oxidative stress. Grx4 is the relevant glutaredoxin that regulates Slt2 phosphorylation under oxidative conditions precluding cell survival. Our studies contribute to extend the functions of both monothiol glutaredoxins to the regulation of a MAPK in the context of the oxidative stress response.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28007574</PMID>
<DateCompleted><Year>2017</Year>
<Month>12</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>05</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-4596</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>103</Volume>
<PubDate><Year>2017</Year>
<Month>02</Month>
</PubDate>
</JournalIssue>
<Title>Free radical biology & medicine</Title>
<ISOAbbreviation>Free Radic Biol Med</ISOAbbreviation>
</Journal>
<ArticleTitle>Physical interaction between the MAPK Slt2 of the PKC1-MAPK pathway and Grx3/Grx4 glutaredoxins is required for the oxidative stress response in budding yeast.</ArticleTitle>
<Pagination><MedlinePgn>107-120</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0891-5849(16)31123-6</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.freeradbiomed.2016.12.023</ELocationID>
<Abstract><AbstractText>This study demonstrates that both monothiol glutaredoxins Grx3 and Grx4 physically interact with the MAPK Slt2 forming a complex involved in the cellular response to oxidative stress. The simultaneous absence of Grx3 and Grx4 provokes a serious impairment in cell viability, Slt2 activation and Rlm1 transcription in response to oxidative stress. Both in vivo and in vitro results clearly show that Slt2 can independently bind either Grx3 or Grx4 proteins. Our results suggest that Slt2 form iron/sulphur bridged clusters with Grx3 and Grx4. For the assembly of this complex, cysteines of the active site of each Grx3/4 glutaredoxins, glutathione and specific cysteine residues from Slt2 provide the ligands. One of the ligands of Slt2 is required for its dimerisation upon oxidative treatment and iron repletion. These interactions are relevant for the oxidative response, given that mutants in the cysteine ligands identified in the complex show a severe impairment of both cell viability and Slt2 phosphorylation upon oxidative stress. Grx4 is the relevant glutaredoxin that regulates Slt2 phosphorylation under oxidative conditions precluding cell survival. Our studies contribute to extend the functions of both monothiol glutaredoxins to the regulation of a MAPK in the context of the oxidative stress response.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pujol-Carrion</LastName>
<ForeName>Nuria</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Basic Medical Sciences, IRB-Lleida. University of Lleida, Av. Alcalde Rovira Roure no 80, 25198 Lleida, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Torre-Ruiz</LastName>
<ForeName>Maria Angeles de la</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Department of Basic Medical Sciences, IRB-Lleida. University of Lleida, Av. Alcalde Rovira Roure no 80, 25198 Lleida, Spain. Electronic address: madelatorre@cmb.udl.cat.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>12</Month>
<Day>20</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Free Radic Biol Med</MedlineTA>
<NlmUniqueID>8709159</NlmUniqueID>
<ISSNLinking>0891-5849</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D054477">Glutaredoxins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C516012">Grx4 protein, S cerevisiae</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.-</RegistryNumber>
<NameOfSubstance UI="C545181">Grx3 protein, S cerevisiae</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.-</RegistryNumber>
<NameOfSubstance UI="D010088">Oxidoreductases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.24</RegistryNumber>
<NameOfSubstance UI="D020928">Mitogen-Activated Protein Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.24</RegistryNumber>
<NameOfSubstance UI="C072724">SLT2 protein, S cerevisiae</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054477" MajorTopicYN="N">Glutaredoxins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020935" MajorTopicYN="N">MAP Kinase Signaling System</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020928" MajorTopicYN="N">Mitogen-Activated Protein Kinases</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010084" MajorTopicYN="N">Oxidation-Reduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018384" MajorTopicYN="Y">Oxidative Stress</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010088" MajorTopicYN="N">Oxidoreductases</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054730" MajorTopicYN="N">Protein Interaction Domains and Motifs</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055503" MajorTopicYN="N">Protein Multimerization</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011499" MajorTopicYN="N">Protein Processing, Post-Translational</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Budding yeast</Keyword>
<Keyword MajorTopicYN="Y">Cell survival</Keyword>
<Keyword MajorTopicYN="Y">Glutaredoxins</Keyword>
<Keyword MajorTopicYN="Y">Iron</Keyword>
<Keyword MajorTopicYN="Y">MAPK</Keyword>
<Keyword MajorTopicYN="Y">Oxidative stress</Keyword>
<Keyword MajorTopicYN="Y">PKC1 pathway</Keyword>
<Keyword MajorTopicYN="Y">Signalling</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>08</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2016</Year>
<Month>12</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>12</Month>
<Day>18</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>12</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>12</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>12</Month>
<Day>24</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">28007574</ArticleId>
<ArticleId IdType="pii">S0891-5849(16)31123-6</ArticleId>
<ArticleId IdType="doi">10.1016/j.freeradbiomed.2016.12.023</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Catalogne</li>
</region>
</list>
<tree><country name="Espagne"><region name="Catalogne"><name sortKey="Pujol Carrion, Nuria" sort="Pujol Carrion, Nuria" uniqKey="Pujol Carrion N" first="Nuria" last="Pujol-Carrion">Nuria Pujol-Carrion</name>
</region>
<name sortKey="Torre Ruiz, Maria Angeles De La" sort="Torre Ruiz, Maria Angeles De La" uniqKey="Torre Ruiz M" first="Maria Angeles De La" last="Torre-Ruiz">Maria Angeles De La Torre-Ruiz</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/GlutaredoxinV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000329 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000329 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    GlutaredoxinV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:28007574
   |texte=   Physical interaction between the MAPK Slt2 of the PKC1-MAPK pathway and Grx3/Grx4 glutaredoxins is required for the oxidative stress response in budding yeast.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:28007574" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a GlutaredoxinV1

This area was generated with Dilib version V0.6.37.
Data generation: Wed Nov 18 15:13:42 2020. Site generation: Wed Nov 18 15:16:12 2020

	Serveur d'exploration sur la glutarédoxine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la glutarédoxine

Physical interaction between the MAPK Slt2 of the PKC1-MAPK pathway and Grx3/Grx4 glutaredoxins is required for the oxidative stress response in budding yeast.

Physical interaction between the MAPK Slt2 of the PKC1-MAPK pathway and Grx3/Grx4 glutaredoxins is required for the oxidative stress response in budding yeast.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki